Señorita Panamá 2003 was the 21st Señorita Panamá and the 38th Miss Panama contest. The final was held at the Figali Convention Center in Panama City, Panama, on November 26, 2003, and was broadcast live on RPC-TV. Eleven contestants competed; Jessica Rodríguez of Panamá Centro won and was crowned by Stefanie de Roux. On the same night, Melissa Del Carmen Piedrahita of Panamá Centro was named Señorita Panamá World.