Miss Grand Paraguay 2022 was the fifth edition of the national beauty pageant, staged at the Hotel Guaraní Theatre in Asunción. Main activities included a press conference and side competitions on 3 May, the preliminary competition on 5 May, and the grand final on 7 May 2022. The event was broadcast nationwide on Unicanal and streamed via the pageant’s YouTube channel (MGM Producciones). Agatha Leon of Ciudad del Este won the title, crowned by outgoing queen Jimena Sosa, and earned the right to represent Paraguay at Miss Grand International 2022.